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Mechanism and functional efficacy of hydroxyapatite nanopowder

December 20,2018.
As a drug carrier:

Hydroxyapatite nanopowder have many advantages such as good biocompatibility, low pH sensitivity, controllable structure, large drug loading and high encapsulation efficiency, and are widely used as drug carriers. At the same time, the synthetic hydroxyapatite is surface-modified to load a specific drug, and can also solve the problem of release of drug release.

Hydroxyapatite nanopowder

Hydroxyapatite is the main component of human teeth and osteophytes:

The hydroxyapatite nanopowderl is similar to the human bone structure and has similar biocompatibility, and is widely used in bone defect repair. Nano-sized fibrous hydroxyapatite or porous network hydroxyapatite prepared by controlled conditions, the surface of the material is favorable for the attachment of osteoblasts, and the pore structure is beneficial to the growth and differentiation of osteoblasts, and can promote bone repair and growth. At the same time, in combination with other antibacterial means, it will be a dual-effect material with bone growth and anti-infection, which is a research hotspot.
Hydroxyapatite nanopowder

As an anti-tumor "new weapon":

Studies have shown that nano-hydroxyapatite exhibits excellent anti-tumor activity, and its anti-tumor mechanism is a mitochondria-dependent apoptotic pathway and a negative regulation of the PIK3/AKT pathway for the development of advanced biocompatible nanocrystals for nanomedicine. Has a high value.

Hydroxyapatite nanopowder

Nano-hydroxyapatite performance advantage

1. Good biocompatibility and stability, large specific surface area, biodegradable, inherent antibacterial activity,
Rich in modification sites
2. Low cost and simple preparation process
Application prospects
Simple hydroxyapatite materials have not been able to meet today's needs, more are seeking
The combination of hydroxyapatite and other materials, which plays a role in the excellent properties of hydroxyapatite
Based on the development of multi-functional composite materials:
Hydroxyapatite is combined with Au and Ag to obtain a composite material having an antibacterial effect;
Hydroxyapatite combined with carbon dots,
Anti-tumor composite materials utilizing carbon dot radiation properties;
Magnetic iron oxide combined with hydroxyapatite,
A targeted anti-tumor drug carrier or the like is obtained.

Hydroxyapatite nanopowder

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