What Is The Advantages Of Nano Gold Powder As A Marker

what is the advantages of nano gold powder as a marker

December 16,2021.

1. The history of nano gold powder development
In 1885, nano gold solution was often used as the main ingredient in the treatment of alcoholism in the United States;
In 1890, Dr. Koch discovered that Mycobacterium tuberculosis could not survive on the surface of gold;
Nano gold was used to treat arthritis in 1890;
In 1935, Chicago surgical expert Edward et al. discovered that nano-gold solution can effectively relieve patients' pain and strengthen their physique.
In 1939, Kausche and Ruska used an electron microscope to observe the tobacco mosaic virus labeled with gold particles, which was in the form of fine particles with high electron density.
In 1971, Faulk and Taylor used immunogold staining (IGS) for the first time to combine rabbit anti-Salmonella antiserum with nano-gold particles, and used direct immunocytochemistry to detect the surface antigen of Salmonella, and pioneered nano-gold immunolabeling technology.
It can be seen that nano-gold has been on the stage of science very early.

Second, the main application of nano gold powder

1. The application of nano gold technology in food safety rapid detection
Nano-gold is used more and more widely in modern food analysis and inspection, mainly due to the short time-consuming detection of nano gold, small sample loss, simple operation technology requirements, high sensitivity, strong specificity, low price and other advantages, especially The rapid measurement technology can adapt to the modern high-efficiency, fast pace and meet the requirements of society.
Nano gold detection is mainly used for the detection of veterinary drug residues, animal infectious diseases, pesticide residues, pathogenic microorganisms, and mycomycin. etc.

2. Nano Gold Marking Technology

As one of the four major modern labeling technologies, nanogold labelling technology is essentially a coating process in which proteins and other polymers are adsorbed onto the surface of nanogold particles. The adsorption mechanism may be the negative charge on the surface of the gold nanoparticle, which forms a firm bond with the positive charge group of the protein due to electrostatic adsorption, and will not denature the biomolecules after adsorption. Due to the high electron density of gold particles, the gold-labeled protein At the junction, dark-brown particles can be seen under the microscope. When these markers aggregate in large amounts at the corresponding ligands, red or pink spots can be seen with the naked eye, so they are used in qualitative or semi-quantitative rapid immunoassay methods. Because the spherical gold nanoparticles have a strong adsorption function for proteins, they can bind non-covalently with Staphylococcus protein A, immunoglobulins, toxins, glycoproteins, enzymes, antibiotics, hormones, bovine serum albumin and so on. Become a very useful tool in research and experimentation.

To sum up, the advantages of nano gold powder as a marker are mainly reflected in:
1. Almost all macromolecular substances can be marked by physical adsorption, and the operation is convenient, and the activity of macromolecular substances basically does not change after marking.
2. The equipment is simple, and the gold nano powder is connected to the antigen or antibody, and the rapid diagnosis can be carried out through the visual indirect agglomeration experiment.
3. The specificity of the immunoprobe is strong, but the non-specific adsorption effect is small, and it is less affected by the background of biological tissues.
4. Simple labeling of antibodies, clusterins and hormones, etc., can easily form a stable gold labeling complex, which can be stored for a long time, with a small amount and fast detection speed.
5. Nano gold with different particle diameters can be prepared for multiple labeling
6. Nano-gold has a large electron density, which is especially suitable for TEM or SEM observation. The sensitivity of detecting antigens or antibodies far exceeds that of enzyme reactants.

Third, the manufacturer of nano gold powder

SAT NANO has many years of experience in producing nanoparticles and strong technical force. It has successfully developed a variety of high-purity nano-precious metal powders, such as nano-gold powder, nano-gold dispersion, nano-gold aqueous solution, and nano-gold wire. Customer feedback is very effective. Good and reached a long-term cooperation. To buy nano precious metal powder, the first choice is the nano material expert ---SAT NANO.

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